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UCL Centre for Nerve Engineering




56: Berg M, Eleftheriadou D, Phillips JB, Shipley RJ. Mathematical modelling with Bayesian inference to quantitatively characterise therapeutic cell behaviour in nerve tissue engineering. J R Soc Interface. 2023, Sep 20(206):20230258. doi: 10.1098/rsif.2023.0258.

55: Guillemot-Legris O, Girmahun G, Shipley RJ, Phillips JB. Local administration of minocycline improves nerve regeneration in two rat nerve injury models. Int J Mol Sci. 2023, 24(15), 12085.

54: Wilcox M, Rayner MLD, Guillemot-Legris O, Platt I, Brown H, Quick T, Phillips
JB. Serum neurofilament light chain measurements following nerve trauma. J
Peripher Nerv Syst. 2023 Jun 22. doi: 10.1111/jns.12576. Epub ahead of print.
PMID: 37349878.

53: Atkinson E, Dickman R. Growth factors and their peptide mimetics for
treatment of traumatic brain injury. Bioorg Med Chem. 2023 Jul 15;90:117368.
doi: 10.1016/j.bmc.2023.117368. Epub 2023 Jun 10. PMID: 37331175.

52: Trueman RP, Finn PG, Westwood MM, Dey A, Palgrave R, Tabor A, Phillips JB,
Schroeder BC. Improving the biological interfacing capability of
diketopyrrolopyrrole polymers <i>via</i> p-type doping. J Mater Chem C Mater.
2023 May 11;11(21):6943-6950. doi: 10.1039/d3tc01148h. PMID: 37274026; PMCID:

51: Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S,
Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B,
McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A,
Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E,
Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT,
Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL,
Vanhaesebroeck B. A small-molecule PI3Kα activator for cardioprotection and
neuroregeneration. Nature. 2023 Jun;618(7963):159-168. doi:
10.1038/s41586-023-05972-2. Epub 2023 May 24. PMID: 37225977; PMCID: PMC7614683.

50: Huang Z, Powell R, Kankowski S, Phillips JB, Haastert-Talini K. Culture
Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-
Centre Study. Int J Mol Sci. 2023 Mar 10;24(6):5366. doi: 10.3390/ijms24065366.
PMID: 36982441; PMCID: PMC10049204.

49: Laranjeira S, Roberton VH, Phillips JB, Shipley RJ. Perspectives on
optimizing local delivery of drugs to peripheral nerves using mathematical
models. WIREs Mech Dis. 2023 Mar;15(2):e1593. doi: 10.1002/wsbm.1593. Epub 2023
Jan 9. PMID: 36624330.

48: Rayner MLD, Kellaway SC, Kingston I, Guillemot-Legris O, Gregory H, Healy J,
Phillips JB. Exploring the Nerve Regenerative Capacity of Compounds with
Differing Affinity for PPARγ In Vitro and In Vivo. Cells. 2022 Dec 22;12(1):42.
doi: 10.3390/cells12010042. PMID: 36611836; PMCID: PMC9818498.

47: Roberton VH, Gregory HN, Angkawinitwong U, Mokrane O, Boyd AS, Shipley RJ,
Williams GR, Phillips JB. Local delivery of tacrolimus using electrospun poly-ϵ-
caprolactone nanofibres suppresses the T-cell response to peripheral nerve
allografts. J Neural Eng. 2023 Jan 30;20(1). doi: 10.1088/1741-2552/acad2a.
PMID: 36538818.

46: Kellaway SC, Roberton V, Jones JN, Loczenski R, Phillips JB, White LJ.
Engineered neural tissue made using hydrogels derived from decellularised
tissues for the regeneration of peripheral nerves. Acta Biomater. 2023
Feb;157:124-136. doi: 10.1016/j.actbio.2022.12.003. Epub 2022 Dec 7. PMID:

45: Roberton VH, Phillips JB. Considerations for the use of biomaterials to
support cell therapy in neurodegenerative disease. Int Rev Neurobiol.
2022;166:191-205. doi: 10.1016/bs.irn.2022.09.009. Epub 2022 Oct 22. PMID:

44: Sanjuan-Alberte P, Whitehead C, Jones JN, Silva JC, Carter N, Kellaway S,
Hague RJM, Cabral JMS, Ferreira FC, White LJ, Rawson FJ. Printing biohybrid
materials for bioelectronic cardio-3D-cellular constructs. iScience. 2022 Jun
7;25(7):104552. doi: 10.1016/j.isci.2022.104552. PMID: 35784786; PMCID:

43: Eleftheriadou D, Berg M, Phillips JB, Shipley RJ. A combined experimental
and computational framework to evaluate the behavior of therapeutic cells for
peripheral nerve regeneration. Biotechnol Bioeng. 2022 Jul;119(7):1980-1996.
doi: 10.1002/bit.28105. Epub 2022 May 2. PMID: 35445744; PMCID: PMC9323509.

42: Eleftheriadou D, Evans RE, Atkinson E, Abdalla A, Gavins FKH, Boyd AS,
Williams GR, Knowles JC, Roberton VH, Phillips JB. An alginate-based
encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 2022
Feb 1;12(7):4005-4015. doi: 10.1039/d1ra08563h. PMID: 35425456; PMCID:

41: Laranjeira S, Pellegrino G, Bhangra KS, Phillips JB, Shipley RJ. <i>In
silico</i> framework to inform the design of repair constructs for peripheral
nerve injury repair. J R Soc Interface. 2022 Mar;19(188):20210824. doi:
10.1098/rsif.2021.0824. Epub 2022 Mar 2. PMID: 35232275; PMCID: PMC8889181.

40: Barrett P, Quick TJ, Mudera V, Player DJ. Neuregulin 1 Drives Morphological
and Phenotypical Changes in C2C12 Myotubes: Towards <i>De Novo</i> Formation of
Intrafusal Fibres <i>In Vitro</i>. Front Cell Dev Biol. 2022 Jan 11;9:760260.
doi: 10.3389/fcell.2021.760260. PMID: 35087826; PMCID: PMC8787273.

39: Barrett P, Quick TJ, Mudera V, Player DJ. Generating intrafusal skeletal
muscle fibres <i>in vitro</i>: Current state of the art and future challenges. J
Tissue Eng. 2020 Dec 29;11:2041731420985205. doi: 10.1177/2041731420985205.
PMID: 34956586; PMCID: PMC8693220.

38: Wilcox M, Dos Santos Canas L, Hargunani R, Tidswell T, Brown H, Modat M,
Phillips JB, Ourselin S, Quick T. Author Correction: Volumetric MRI is a
promising outcome measure of muscle reinnervation. Sci Rep. 2021 Dec
6;11(1):23794. doi: 10.1038/s41598-021-03254-3. Erratum for: Sci Rep. 2021 Nov
17;11(1):22433. PMID: 34873264; PMCID: PMC8648783.

37: Trueman RP, Ahlawat AS, Phillips JB. A Shock to the (Nervous) System:
Bioelectricity Within Peripheral Nerve Tissue Engineering. Tissue Eng Part B
Rev. 2022 Oct;28(5):1137-1150. doi: 10.1089/ten.TEB.2021.0159. Epub 2022 Apr 4.
PMID: 34806913.

36: Wilcox M, Dos Santos Canas L, Hargunani R, Tidswell T, Brown H, Modat M,
Phillips JB, Ourselin S, Quick T. Volumetric MRI is a promising outcome measure
of muscle reinnervation. Sci Rep. 2021 Nov 17;11(1):22433. doi:
10.1038/s41598-021-01342-y. Erratum in: Sci Rep. 2021 Dec 6;11(1):23794. PMID:
34789795; PMCID: PMC8599480.

35: Rayner MLD, Healy J, Phillips JB. Repurposing Small Molecules to Target
PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules. 2021 Sep
1;11(9):1301. doi: 10.3390/biom11091301. PMID: 34572514; PMCID: PMC8465622.

34: Gilbert AW, May CR, Brown H, Stokes M, Jones J. A qualitative investigation
into the results of a discrete choice experiment and the impact of COVID-19 on
patient preferences for virtual consultations. Arch Physiother. 2021 Sep
6;11(1):20. doi: 10.1186/s40945-021-00115-0. PMID: 34488898; PMCID: PMC8419808.

33: Rayner MLD, Day AGE, Bhangra KS, Sinden J, Phillips JB. Engineered neural
tissue made using clinical-grade human neural stem cells supports regeneration
in a long gap peripheral nerve injury model. Acta Biomater. 2021
Nov;135:203-213. doi: 10.1016/j.actbio.2021.08.030. Epub 2021 Aug 26. PMID:

32: Phillips JB. ‘EngNT’ – Engineering live neural tissue for nerve replacement.
Emerg Top Life Sci. 2021 Nov 12;5(5):699-703. doi: 10.1042/ETLS20210085. PMID:
34297065; PMCID: PMC8726050.

31: Coy R, Berg M, Phillips JB, Shipley RJ. Modelling-informed cell-seeded nerve
repair construct designs for treating peripheral nerve injuries. PLoS Comput
Biol. 2021 Jul 8;17(7):e1009142. doi: 10.1371/journal.pcbi.1009142. PMID:
34237052; PMCID: PMC8266098.

30: Powell R, Eleftheriadou D, Kellaway S, Phillips JB. Natural Biomaterials as
Instructive Engineered Microenvironments That Direct Cellular Function in
Peripheral Nerve Tissue Engineering. Front Bioeng Biotechnol. 2021 May
25;9:674473. doi: 10.3389/fbioe.2021.674473. PMID: 34113607; PMCID: PMC8185204.

29: Muangsanit P, Roberton V, Costa E, Phillips JB. Engineered aligned
endothelial cell structures in tethered collagen hydrogels promote peripheral
nerve regeneration. Acta Biomater. 2021 May;126:224-237. doi:
10.1016/j.actbio.2021.03.039. Epub 2021 Mar 22. PMID: 33766800.

28: Powell R, Phillips JB. Engineered Tissues Made from Human iPSC-Derived
Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro. Methods
Mol Biol. 2021;2269:245-254. doi: 10.1007/978-1-0716-1225-5_17. PMID: 33687684.

27: Wilcox M, Laranjeira S, Brown H, Quick T. How to assess the recovery of
muscular function following nerve injury: A view from surgeons and patients. J
Plast Reconstr Aesthet Surg. 2021 Jul;74(7):1594-1601. doi:
10.1016/j.bjps.2020.11.030. Epub 2020 Dec 11. PMID: 33422494.

26: Gregory H, Phillips JB. Materials for peripheral nerve repair constructs:
Natural proteins or synthetic polymers? Neurochem Int. 2021 Feb;143:104953. doi:
10.1016/j.neuint.2020.104953. Epub 2020 Dec 31. PMID: 33388359.

25: Wilcox M, Gregory H, Powell R, Quick TJ, Phillips JB. Strategies for
Peripheral Nerve Repair. Curr Tissue Microenviron Rep. 2020;1(2):49-59. doi:
10.1007/s43152-020-00002-z. Epub 2020 Apr 21. PMID: 33381765; PMCID: PMC7749870.

24: Wilcox MB, Jessen KR, Quick TJ, Phillips JB. The molecular profile of nerve
repair: humans mirror rodents. Neural Regen Res. 2021 Jul;16(7):1440-1441. doi:
10.4103/1673-5374.301014. PMID: 33318445; PMCID: PMC8284295.

23: Huang Z, Powell R, Phillips JB, Haastert-Talini K. Perspective on Schwann
Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue
Engineering. Cells. 2020 Nov 17;9(11):2497. doi: 10.3390/cells9112497. PMID:
33213068; PMCID: PMC7698557.

22: Merrison H, Mangtani A, Quick T. The shifting demographics of birth-related
brachial plexus injury: The impact of socio-economic status and ethnic groups. J
Plast Reconstr Aesthet Surg. 2021 Mar;74(3):560-568. doi:
10.1016/j.bjps.2020.08.091. Epub 2020 Sep 10. PMID: 33039306.

21: Simpson AI, Vaghela KR, Brown H, Adams K, Sinisi M, Fox M, Quick T. Reducing
the Risk and Impact of Brachial Plexus Injury Sustained From Prone Positioning-A
Clinical Commentary. J Intensive Care Med. 2020 Dec;35(12):1576-1582. doi:
10.1177/0885066620954787. Epub 2020 Sep 22. PMID: 32959717.

20: Eleftheriadou D, Kesidou D, Moura F, Felli E, Song W. Redox-Responsive
Nanobiomaterials-Based Therapeutics for Neurodegenerative Diseases. Small. 2020
Oct;16(43):e1907308. doi: 10.1002/smll.201907308. Epub 2020 Sep 17. PMID:

19: Bartlett RD, Eleftheriadou D, Evans R, Choi D, Phillips JB. Mechanical
properties of the spinal cord and brain: Comparison with clinical-grade
biomaterials for tissue engineering and regenerative medicine. Biomaterials.
2020 Nov;258:120303. doi: 10.1016/j.biomaterials.2020.120303. Epub 2020 Aug 11.
PMID: 32858388.

18: Rayner MLD, Grillo A, Williams GR, Tawfik E, Zhang T, Volitaki C, Craig DQM,
Healy J, Phillips JB. Controlled local release of PPARγ agonists from
biomaterials to treat peripheral nerve injury. J Neural Eng. 2020 Aug
11;17(4):046030. doi: 10.1088/1741-2552/aba7cc. PMID: 32780719.

17: Muangsanit P, Day A, Dimiou S, Ataç AF, Kayal C, Park H, Nazhat SN, Phillips
JB. Rapidly formed stable and aligned dense collagen gels seeded with Schwann
cells support peripheral nerve regeneration. J Neural Eng. 2020 Aug
25;17(4):046036. doi: 10.1088/1741-2552/abaa9c. PMID: 32726759.

16: Bartlett RD, Burley S, Ip M, Phillips JB, Choi D. Cell Therapies for Spinal
Cord Injury: Trends and Challenges of Current Clinical Trials. Neurosurgery.
2020 Sep 15;87(4):E456-E472. doi: 10.1093/neuros/nyaa149. PMID: 32497197.

15: Wilcox MB, Laranjeira SG, Eriksson TM, Jessen KR, Mirsky R, Quick TJ,
Phillips JB. Characterising cellular and molecular features of human peripheral
nerve degeneration. Acta Neuropathol Commun. 2020 Apr 17;8(1):51. doi:
10.1186/s40478-020-00921-w. PMID: 32303273; PMCID: PMC7164159.

14: Coy R, Al-Badri G, Kayal C, O’Rourke C, Kingham PJ, Phillips JB, Shipley RJ.
Combining <i>in silico</i> and <i>in vitro</i> models to inform cell seeding
strategies in tissue engineering. J R Soc Interface. 2020 Mar;17(164):20190801.
doi: 10.1098/rsif.2019.0801. Epub 2020 Mar 25. PMID: 32208821; PMCID:

13: Rayner MLD, Brown HL, Wilcox M, Phillips JB, Quick TJ. Quantifying
regeneration in patients following peripheral nerve injury. J Plast Reconstr
Aesthet Surg. 2020 Feb;73(2):201-208. doi: 10.1016/j.bjps.2019.10.007. Epub 2019
Oct 11. PMID: 31831264.

12: Kayal C, Moeendarbary E, Shipley RJ, Phillips JB. Mechanical Response of
Neural Cells to Physiologically Relevant Stiffness Gradients. Adv Healthc Mater.
2020 Apr;9(8):e1901036. doi: 10.1002/adhm.201901036. Epub 2019 Dec 2. PMID:
31793251; PMCID: PMC8407326.

11: Gambarotta G, Raimondo S, Udina E, Phillips JB, Haastert-Talini K.
Editorial: Peripheral Nerve Regeneration. Front Cell Neurosci. 2019 Oct
15;13:464. doi: 10.3389/fncel.2019.00464. PMID: 31680873; PMCID: PMC6803521.

10: Lee H, Phillips JB, Hall RM, Tipper JL. Neural cell responses to wear debris
from metal-on-metal total disc replacements. Eur Spine J. 2020
Nov;29(11):2701-2712. doi: 10.1007/s00586-019-06177-w. Epub 2019 Oct 29. PMID:

9: Bartlett RD, Phillips JB, Choi D. Improved cell-purification techniques and
safety monitoring needed for olfactory ensheathing cell transplantation. CMAJ.
2019 Oct 28;191(43):E1199. doi: 10.1503/cmaj.73255. PMID: 31659064; PMCID:

8: Quick TJ, Brown H. Evaluation of functional outcomes after brachial plexus
injury. J Hand Surg Eur Vol. 2020 Jan;45(1):28-33. doi:
10.1177/1753193419879645. Epub 2019 Oct 9. PMID: 31597518.

7: Santiago-Toledo G, Georgiou M, Dos Reis J, Roberton VH, Valinhas A, Wood RC,
Phillips JB, Mason C, Li D, Li Y, Sinden JD, Choi D, Jat PS, Wall IB. Generation
of c-MycER<sup>TAM</sup>-transduced human late-adherent olfactory mucosa cells
for potential regenerative applications. Sci Rep. 2019 Sep 13;9(1):13190. doi:
10.1038/s41598-019-49315-6. PMID: 31519924; PMCID: PMC6744411.

6: Kayal C, Shipley RJ, Phillips JB. Physical and mechanical properties of
RAFT-stabilised collagen gels for tissue engineering applications. J Mech Behav
Biomed Mater. 2019 Nov;99:216-224. doi: 10.1016/j.jmbbm.2019.07.011. Epub 2019
Jul 24. PMID: 31394492.

5: Wilcox M, Brown H, Johnson K, Sinisi M, Quick TJ. An assessment of
fatigability following nerve transfer to reinnervate elbow flexor muscles. Bone
Joint J. 2019 Jul;101-B(7):867-871. doi:
10.1302/0301-620X.101B7.BJJ-2019-0005.R1. PMID: 31256676.

4: Wilcox M, Quick TJ, Phillips JB. The Effects of Surgical Antiseptics and
Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves. Front Cell
Neurosci. 2019 May 22;13:189. doi: 10.3389/fncel.2019.00189. PMID: 31178696;
PMCID: PMC6538796.

3: Rayner MLD, Laranjeira S, Evans RE, Shipley RJ, Healy J, Phillips JB.
Developing an In Vitro Model to Screen Drugs for Nerve Regeneration. Anat Rec
(Hoboken). 2018 Oct;301(10):1628-1637. doi: 10.1002/ar.23918. Epub 2018 Oct 17.
PMID: 30334365; PMCID: PMC6282521.

2: Muangsanit P, Shipley RJ, Phillips JB. Vascularization Strategies for
Peripheral Nerve Tissue Engineering. Anat Rec (Hoboken). 2018
Oct;301(10):1657-1667. doi: 10.1002/ar.23919. Epub 2018 Oct 17. PMID: 30334363;
PMCID: PMC6282999.

1: O’Rourke C, Day AGE, Murray-Dunning C, Thanabalasundaram L, Cowan J,
Stevanato L, Grace N, Cameron G, Drake RAL, Sinden J, Phillips JB. An allogeneic
‘off the shelf’ therapeutic strategy for peripheral nerve tissue engineering
using clinical grade human neural stem cells. Sci Rep. 2018 Feb 13;8(1):2951.
doi: 10.1038/s41598-018-20927-8. PMID: 29440680; PMCID: PMC5811594.

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