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UCL Centre for Nerve Engineering


Seminars and Events

2017/2018 Seminar Series

All Malet Place Engineering (Room 1.03) and 4-5 pm, unless otherwise stated.
  • 07-11-2017 (1-2pm, L2, Eastman Dental Institute) – Prof. Heinz Redl (Ludwig Boltzmann Institute for Experimental and Clinical Traumatology) –  Austrian Cluster for Tissue Regeneration – Neuro and Musculoskeletal Target Areas
  • 11-12-2017 Mr David Choi (National Hospital for Neurology and Neurosurgery, Institute of Neurology)
    Olfactory Ensheathing Cells and Regenerative Medicine.
  • 26-01-2018 Dr Siobhan McMahon (REMEDI, Galway)
    The Glial and Glyomic Responses to Spinal Cord Injury in Regenerating Zenopus and Collagen Hydrogel Treated Rats
    Location: Room 225 UCL School of Pharmacy
    Time: 12:30pm

    Further information available here

  • 08-02-2018 Mr Tom Quick (Royal National Orthopaedic Hospital)
    Nerve Injury – A Clinician’s View
    A 360 degree presentation of the current experience of nerve injury.-The clinical work in treating peripheral nerve injury as seen through NHS practice. The major conditions seen in the NHS and their common treatment.-Brachial plexus surgery as seen through the Surgeon’s eyes: Operative video documentation and discussion of the challenges in treatment-Symptoms of injury and recovery from the patient’s view point. Focus group assessment and patient survey data on the lived experience and what better feels like.
  • 13-03-2018 (Malet Place Engineering Room 1.02) Prof. David Holder (UCL Department of Medical Physics and Biomedical Engineering)
    EIT imaging and selective neuromodulation in complex peripheral nervesUnderstanding the coding of neural activity in peripheral nerves, particularly within nerve fascicles and their poorly understood neuroanatomy, is a high priority in electroceutical autonomic nerve stimulation and functional electrical stimulation for treatment of paraplegia. Although neuromodulation is widely used for the treatment of epilepsy and neuroprosthetics, there could be huge benefits from improved spatial resolution. Currently, no technique can non-invasively image neuronal action potentials within nerve fibres in peripheral nerves. We present a novel method for achieving this, using a flexible cylindrical multi-electrode cuff placed around the nerve and the new medical imaging technique of fast neural Electrical Impedance Tomography (EIT). In the rat, with a cuff around the sciatic nerve, it was possible to distinguish separate fascicles activated in response to direct electrical stimulation of the posterior tibial and common peroneal nerves. With this novel application, we imaged mammalian peripheral autonomic nerves, which presented many new challenges including inadequate signal-to-noise, variable neuroanatomy, and neuronal dispersion were discovered. To this end we present recent advances in electrode fabrication that offer improvements in electrical performance resulting in improved accuracy of EIT reconstruction. Additionally, we have demonstrated that using our non-invasive multi-contact electrode cuff it is possible to selectively stimulate at different points around the circumference of the nerve. This has the potential to significantly improve stimulation efficacy in the next generation of implanted devices. Ultimately, we are working towards the grand vision of using a single implanted EIT cuff to create a map of single neuronal events in the peripheral nerve that can be used to identify target nerve fibres that are driving specific disease states, then using this map to aid in designing informed therapeutically intervening selective stimulation paradigms.
  • 09-04-2018 TBC

CNE Networking Event - Autumn 2017

The aim of this event is to bring together the communities at UCL and UCL Hospitals undertaking research relevant to nerve engineering, and to promote new collaborations and projects. It will take place on Tuesday 28th November, 2-5pm in G11 at Senate House, and will include a combination of short research talks and poster sessions. All are welcome – please email us if you would like more information.

2-3pm Introductions and Short Talks

Kristjan Jessen – Why do repair Schwann cells fail?

James Phillips – Using cells, drugs and tissue engineering to repair nerves

Ivana Drobnjak – Microstructure Imaging of Nerves with Diffusion MRI

Simon Walker-Samuel – Imaging and simulating tissue microstructure

Nader Saffari – Ultrasound-mediated neuromodulation in the peripheral nervous system

3-4pm Posters and Refreshments

4-5pm Short Talks

David Holder – Imaging fascicular activity in nerves with Electrical Impedance Tomography (EIT)

Gareth Williams – The Hydrogel that Jack Built

Becky Shipley – Mathematical Modelling for Nerve Tissue Engineering

Sunthar Mahalingam – On Novel Advanced Forming for Nerve Tissue Engineering

Nick Ovenden – Structural Mechanics of Nerve Tissue

Jess Healy – Kinetic target guided synthesis as a tool for chemical biology and drug discovery


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