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UCL Centre for Nerve Engineering


New Publication: `Off the shelf’ living replacement nerve tissue

New Publication: `Off the shelf’ living replacement nerve tissue

C O’Rourke et al.
An Allogeneic ‘Off The Shelf’ Therapeutic Strategy for Peripheral Nerve Tissue Engineering Using Clinical Grade Human Neural Stem Cells
Scientific Reports 8 (2018)

This paper, published in Nature Scientific Reports, reports a study in which engineered neural tissue (EngNT) was made using ReNeuron‘s clinical grade stem cells and tested in a nerve injury model using athymic nude rats. This approach offers the possibility of developing an Advanced Therapy Medicinal Product (ATMP) using allogeneic cells which could potentially be suitable for implantation into patients with severe nerve injury. If it can be successfully translated to the clinic then this type of ‘off the shelf’ engineered tissue approach overcomes the limitations of current clinical nerve autograft treatments and avoids the delay and variability associated with tissue engineering using autologous cells.

More information is available through this UCL research news item.

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